ABSTRACT
Thirty-five new patients with squamous cell carcinoma of the cervix stage II and III, with refusal of radiation therapy were treated with a single dose of mitomycin-C 35 mg/m2 intrabifurcation of the aorta infusion. 85.7 percent had clinically complete regression and 5.71 percent had partial regression. Twenty-seven cases of the clinically complete regression were treated by radical hysterectomy and pelvic nodes dissection. There were 10 cases (37.03%) showing pathologically complete regression, 11 cases (40.74%) showing small residual cancer in the cervix and 6 cases (22.22%) showing residual cancer in the cervix and pelvic nodes. The follow up performed after 18-30 months, revealed recurrence or metastases in 18.51 percent of the cases. Mild nausea, alopecia, weakness, anorexia, moderately depressed in the second week after treatment.